Heterogenous vasodilator pathways underlie flow-mediated dilation in men and women
نویسندگان
چکیده
منابع مشابه
Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging
Background. Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown. Methods. FMD was measured in older adults (n = 10, 65 ± 3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA. Data were compared to...
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BACKGROUND Endothelial dysfunction is associated with atherosclerosis and may contribute to ischemic syndromes. We assessed the contribution of endothelium-derived nitric oxide (NO) and vasodilator prostanoids to resting blood flow, metabolic vasodilation, and flow reserve in the human coronary circulation. METHODS AND RESULTS Coronary hemodynamics were assessed before and after inhibition of...
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In this edition of Hypertension, the Framingham Heart Study group reports on the relationship between diastolic shear stress and brachial artery flow mediated dilation (FMD) in 2045 participants of the Framingham Offspring group.1 Clinical correlates and heritability of FMD in the participants have been published previously.2 The new report1 challenges conventional concepts on endothelial funct...
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A CORNERSTONE OF THE “exercise is medicine” movement is that regular exercise has widespread health benefits. Compared with the number of studies that have characterized health outcomes, relatively few address the mechanisms for the health outcomes. The study by Birk et al. (1) in the Journal of Applied Physiology presents evidence for the role of increased blood flow as the mechanism for enhan...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2011
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00400.2011